The "Me And The Boys" meme features a distorted image of four Spider-Man villains – Rhino, Vulture, Electro, and Green Goblin – from the 1967 animated series. Their original animated mouths are replaced with realistic, grinning human mouths, creating a distinctively unsettling and humorous effect. The meme surged in popularity around 2019. It is typically used to caption scenarios involving a group of male friends (the "boys") who are about to embark on a shared, often mischievous, silly, or chaotic activity. It captures a feeling of camaraderie, shared excitement, and impending fun or trouble, often with an underlying tone of dark humor or ironic self-awareness about their collective antics.